Epigenetic contribution to stress adaptation in the parasite Entamoeba histolytica

Entamoeba histolytica is an intestinal parasite responsible for amebiasis. Approximately 50 million people have invasive disease annually resulting in 100,000 deaths per year making it the second most common cause of parasitic death in humans. The vegetative stages (trophozoites) of E. histolytica live in the large intestine and form encysted stages (cysts) that are excreted with feces. The trophozoites can penetrate into the intestinal wall and invade the liver and other organs to produce clinical forms of amebosis, most frequently intestinal amebosis and hepatic amebosis (amoebic liver abscess). The infection is transmitted by cysts from one human to another due to transmission of mature cysts with foods (fruit vegetables) and drinking water contaminated with fecal material. Inside its human host, the parasite is challenged by various stressful conditions that originate in part from the immune system of its human host (like the production of nitric oxide by phagocytes).

The main goal of our laboratory is to understand the role of epigenetic processes in controlling the adaptation of the parasite to environmental stresses